SAN FRANCISCO — Psychedelic musical chameleons Osees played the first of four sold-out shows at The Chapel on Sunday night. One of the busiest bands in show business, was fresh off the release of new album Intercepted Message and a string of shows in Europe, with the San Francisco residency an early stop on a U.S. tour this month.

Even with all that on its plate, the quintet fronted by John Dwyer still sets up its own gear. It’s a rare move for bands who aren’t still paying their dues in dive bars, but embodies Osees’ hands-on approach to music making. Anticipation grew as Dwyer and company busied themselves plugging in and tuning up their instruments. After a couple bars of Pink Floyd’s “Interstellar Overdrive,” the band was ready and the audience hyped.

As Osees launched into “I Came From the Mountain,” from their 2013 album Floating Coffin, a huge mosh pit opened in the crowd. In fact, the energy in the audience grew with each of the first three songs, each from older albums including “Static God” from Orc, and “The Dream” from 2011’s Carrion Crawler/The Dream. By the end of the third song, the evening’s first crowd surfers appeared.

The set’s musical fare varied between blistering punk, spaced-out synth jams, Krautrock grooves and free-jazz-like musical freak-outs — sometimes all in the same song. One epic jam melded the garage band surf rock of “Chem Farmer” to the creepy synth-pop of “Nite Expo.” Synth-heavy tracks from the new album included, “Stunner” and “Black Chem.” “Sticky Husk,” with its seasick guitar riffs and lush synth strings, managed to combine the disparate vibes.

The most enthusiastic crowd surfing and mosh pit of the evening was reserved for “Tidal Wave,” which Dwyer, glancing off stage, dedicated to “my sister, Brigid Dawson,” who played keyboards for the band until about five years ago.

The band closed with an epic version of “C,” from 2018 album Smote Reverser. During the extended jam that ventured from the stoned trucker’s groove of the studio version all the way to ambient noise and back again, Dwyer left the stage only to return with five beers for the band.

Even after a marathon set clocking in at nearly two hours, mixing live show standards with some of the band’s newer material, the crowd still wanted more. Attendees stomping their feet and chanting even after the Chapel’s staff turned on the house lights and piped in music.

San Francisco band Fantasy SF opened the show with a high-energy 45-minute set. The quartet, donning matching track suits, took to their combination of punk, funk and rock and roll to the crowded stage. Guitarist and vocalist Bryan Cain announced the band as “agents of chaos” before showing off with a number of high kicks during the performance. Cain’s vocal harmonies with guitarist Kirk Markopoulos were especially powerful during a somewhat Weezer-esque song with the recurring line, “You smell great!”

A difference band will open each of the remaining three nights on this San Francisco residency.